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The main causes of migraine include mutations in the MTHFR gene, atypical vitamin D levels, the presence of inflammatory mediators in the environment of nerves and cerebrospinal fluid, reduced serotonin levels, impaired mitochondrial functionality, and reduced metabolic enzyme activity [9, 10]

The categorical variables were contrasted utilizing Chi-square test or Fishers exact test

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307,308,309 Endothelial dysfunction is well recognized in DPN